Compound Detail
CHEMBL16782
7-METHOXYFLAVONE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL16782 |
| Name | 7-METHOXYFLAVONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QKNDCRMJDZLFEG-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
15
Publications
0
Known Names
Molecular Properties
252.3
MW (Da)
3.47
ALogP
3
HBA
0
HBD
39.4
PSA (Ų)
0.70
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Aromatase CHEMBL1978 | IC50 | 6.29 | 5.17 | 510.0 | 2 |
| Poly [ADP-ribose] polymerase tankyrase-1 CHEMBL6164 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Aromatase | IC50 | = | 510.0 | nM | 6.29 | Inhibition of recombinant CYP19A1 (unknown origin) using dibenzylfluorescein as ... | 35576701 |
| Poly [ADP-ribose] polymerase tankyrase-1 | IC50 | = | 5000.0 | nM | 5.3 | Inhibition of human TNKS1 (1030 to 1317) using NAD+ as substrate by fluorescence... | 24116873 |
| Aromatase | IC50 | = | 88715.6 | nM | 4.05 | Inhibition of human aromatase using ASD as substrate pre-incubated for 5 mins fo... | 28622580 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8523407 | 10.1021/jm00025a011 | Rattus norvegicus | 6 |
| 19592245 | 10.1016/j.bmcl.2009.06.073 | Glucocorticoid receptor | 2 |
| 20415424 | 10.1021/jf100073j | Spodoptera frugiperda | 2 |
| 28408221 | 10.1016/j.bmcl.2017.03.057 | RAW264.7 | 2 |
| 35576701 | 10.1016/j.ejmech.2022.114332 | Cytochrome P450 | 2 |
| 10354396 | 10.1021/jm980441h | Aldo-keto reductase family 1 member B1 | 1 |
| 14980657 | 10.1016/j.bmcl.2003.12.087 | Prostaglandin G/H synthase 2 | 1 |
| 19592245 | 10.1016/j.bmcl.2009.06.073 | Androgen receptor | 1 |
| 20045650 | 10.1016/j.bmc.2009.12.029 | Amine oxidase [flavin-containing] B | 1 |
| 20045650 | 10.1016/j.bmc.2009.12.029 | Amine oxidase [flavin-containing] A | 1 |
| 12517100 | 10.1021/jf025627a | Spodoptera litura | 1 |
| 24116873 | 10.1021/jm401463y | Poly [ADP-ribose] polymerase tankyrase-1 | 1 |
| 35576701 | 10.1016/j.ejmech.2022.114332 | Unchecked | 1 |
| 35576701 | 10.1016/j.ejmech.2022.114332 | Aromatase | 1 |
| 28622580 | 10.1016/j.ejmech.2017.05.041 | Aromatase | 1 |
Data from ChEMBL 36 via Core Engine