Assay Detail
Functional
CHEMBL5115462
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human BT-474 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel pyrazolo [3,4-d]pyrimidine derivatives as potent PLK4 inhibitors for the treatment of TRIM37-amplified breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.10 | 5.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5200125 | — | — | 1 | 5.63 |
| CHEMBL5185001 | — | — | 1 | 5.63 |
| CHEMBL5188129 | — | — | 1 | 5.53 |
| CHEMBL5183346 | — | — | 1 | 5.51 |
| CHEMBL5209160 | — | — | 1 | 5.49 |
| CHEMBL5187941 | — | — | 1 | 5.39 |
| CHEMBL5180759 | — | — | 1 | 5.21 |
| CHEMBL5191641 | — | — | 1 | 5.14 |
| CHEMBL5171233 | — | — | 1 | 5.14 |
| CHEMBL5198607 | — | — | 1 | 5.08 |
| CHEMBL5200865 | — | — | 1 | 5.06 |
| CHEMBL5208535 | — | — | 1 | 5.00 |
| CHEMBL5185225 | — | — | 1 | 4.98 |
| CHEMBL5171469 | — | — | 1 | 4.93 |
| CHEMBL5175172 | — | — | 1 | 4.92 |
| CHEMBL5190548 | — | — | 1 | 4.89 |
| CHEMBL5175294 | — | — | 1 | 4.89 |
| CHEMBL5185324 | — | — | 1 | 4.88 |
| CHEMBL5207473 | — | — | 1 | 4.79 |
| CHEMBL5194020 | — | — | 1 | 4.76 |
| CHEMBL5201909 | — | — | 1 | 4.74 |
| CHEMBL5176789 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5200125 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL5185001 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL5188129 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL5183346 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL5209160 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL5187941 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL5180759 | — | IC50 | = | 6230.0 | nM | 5.21 |
| CHEMBL5191641 | — | IC50 | = | 7240.0 | nM | 5.14 |
| CHEMBL5171233 | — | IC50 | = | 7160.0 | nM | 5.14 |
| CHEMBL5198607 | — | IC50 | = | 8230.0 | nM | 5.08 |
| CHEMBL5200865 | — | IC50 | = | 8750.0 | nM | 5.06 |
| CHEMBL5208535 | — | IC50 | = | 10110.0 | nM | 5.00 |
| CHEMBL5185225 | — | IC50 | = | 10520.0 | nM | 4.98 |
| CHEMBL5171469 | — | IC50 | = | 11710.0 | nM | 4.93 |
| CHEMBL5175172 | — | IC50 | = | 12130.0 | nM | 4.92 |
| CHEMBL5190548 | — | IC50 | = | 13010.0 | nM | 4.89 |
| CHEMBL5175294 | — | IC50 | = | 12850.0 | nM | 4.89 |
| CHEMBL5185324 | — | IC50 | = | 13160.0 | nM | 4.88 |
| CHEMBL5207473 | — | IC50 | = | 16220.0 | nM | 4.79 |
| CHEMBL5194020 | — | IC50 | = | 17340.0 | nM | 4.76 |
| CHEMBL5201909 | — | IC50 | = | 18280.0 | nM | 4.74 |
| CHEMBL5176789 | — | IC50 | = | 19390.0 | nM | 4.71 |