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Assay Detail

CHEMBL5115598

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of tubulin polymerization (unknown origin) by fluorescence based analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Tubulin (CHEMBL2095182)
Type PROTEIN COMPLEX GROUP
Organism Homo sapiens

Publication

Design, synthesis and biological evaluation of new parbendazole derivatives for the treatment of HNSCC.
Liang D, Yu C, Ma Z, Hu M, Wang J, Dong X, Du L, Li M.
Eur J Med Chem (2022) 238 : 114450 -114450
PubMed 35576703 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.38 6.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL159 VINBLASTINE 4.0 1 6.13
CHEMBL67 COMBRETASTATIN A4 -1.0 1 5.83
CHEMBL5170564 1 5.79
CHEMBL5189736 1 5.39
CHEMBL107 COLCHICINE 4.0 1 5.37
CHEMBL5178230 1 5.36
CHEMBL5184981 1 5.36
CHEMBL5197212 1 5.29
CHEMBL5171386 1 5.27
CHEMBL5191842 1 5.20
CHEMBL5171969 1 5.17
CHEMBL528271 PARBENDAZOLE 2.0 1 5.02
CHEMBL5190301 1 4.79

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL159 VINBLASTINE IC50 = 740.0 nM 6.13
CHEMBL67 COMBRETASTATIN A4 IC50 = 1480.0 nM 5.83
CHEMBL5170564 IC50 = 1620.0 nM 5.79
CHEMBL5189736 IC50 = 4040.0 nM 5.39
CHEMBL107 COLCHICINE IC50 = 4280.0 nM 5.37
CHEMBL5178230 IC50 = 4410.0 nM 5.36
CHEMBL5184981 IC50 = 4400.0 nM 5.36
CHEMBL5197212 IC50 = 5080.0 nM 5.29
CHEMBL5171386 IC50 = 5340.0 nM 5.27
CHEMBL5191842 IC50 = 6270.0 nM 5.20
CHEMBL5171969 IC50 = 6810.0 nM 5.17
CHEMBL528271 PARBENDAZOLE IC50 = 9550.0 nM 5.02
CHEMBL5190301 IC50 = 16170.0 nM 4.79