Assay Detail
Functional
CHEMBL5115837
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-proliferative activity against human PC-9 cells assessed as reduction in cell proliferation incubated for 72 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of proteolysis targeting chimeras (PROTACs) as an EGFR degrader based on CO-1686.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.36 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545308 | ROCILETINIB | 3.0 | 1 | 6.57 |
| CHEMBL5206775 | — | — | 1 | 6.30 |
| CHEMBL5175891 | — | — | 1 | 6.12 |
| CHEMBL5201794 | — | — | 1 | 6.05 |
| CHEMBL5196498 | — | — | 1 | 5.87 |
| CHEMBL5204954 | — | — | 1 | 5.72 |
| CHEMBL5196377 | — | — | 1 | 5.59 |
| CHEMBL5197676 | — | — | 1 | 5.59 |
| CHEMBL5198609 | — | — | 1 | 5.48 |
| CHEMBL5194838 | — | — | 1 | 5.46 |
| CHEMBL5185559 | — | — | 1 | 5.46 |
| CHEMBL5194534 | — | — | 1 | 5.43 |
| CHEMBL5176547 | — | — | 1 | 5.33 |
| CHEMBL5179538 | — | — | 1 | 5.31 |
| CHEMBL5201418 | — | — | 1 | 5.28 |
| CHEMBL5207524 | — | — | 1 | 5.18 |
| CHEMBL5200495 | — | — | 1 | 5.17 |
| CHEMBL5175976 | — | — | 1 | 5.13 |
| CHEMBL5176846 | — | — | 1 | 5.12 |
| CHEMBL5208802 | — | — | 1 | 5.06 |
| CHEMBL5193965 | — | — | 1 | 4.88 |
| CHEMBL5186880 | — | — | 1 | 4.87 |
| CHEMBL5203490 | — | — | 1 | 4.84 |
| CHEMBL5182398 | — | — | 1 | 4.74 |
| CHEMBL5208186 | — | — | 1 | 4.57 |
| CHEMBL5180910 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545308 | ROCILETINIB | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5206775 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5175891 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5201794 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5196498 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL5204954 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL5196377 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL5197676 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL5198609 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL5194838 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL5185559 | — | IC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL5194534 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL5176547 | — | IC50 | = | 4620.0 | nM | 5.33 |
| CHEMBL5179538 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL5201418 | — | IC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL5207524 | — | IC50 | = | 6610.0 | nM | 5.18 |
| CHEMBL5200495 | — | IC50 | = | 6740.0 | nM | 5.17 |
| CHEMBL5175976 | — | IC50 | = | 7340.0 | nM | 5.13 |
| CHEMBL5176846 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL5208802 | — | IC50 | = | 8770.0 | nM | 5.06 |
| CHEMBL5193965 | — | IC50 | = | 13190.0 | nM | 4.88 |
| CHEMBL5186880 | — | IC50 | = | 13390.0 | nM | 4.87 |
| CHEMBL5203490 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL5182398 | — | IC50 | = | 18090.0 | nM | 4.74 |
| CHEMBL5208186 | — | IC50 | = | 26650.0 | nM | 4.57 |
| CHEMBL5180910 | — | IC50 | = | 46480.0 | nM | 4.33 |