Assay Detail
Binding
CHEMBL5115839
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type EGFR (unknown origin) incubated for 10 mins by HTRF KinEASE-TK assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of proteolysis targeting chimeras (PROTACs) as an EGFR degrader based on CO-1686.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.13 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545308 | ROCILETINIB | 3.0 | 1 | 7.12 |
| CHEMBL5206775 | — | — | 1 | 6.44 |
| CHEMBL5200495 | — | — | 1 | 6.21 |
| CHEMBL5201794 | — | — | 1 | 6.19 |
| CHEMBL5175891 | — | — | 1 | 6.08 |
| CHEMBL5204954 | — | — | 1 | 5.85 |
| CHEMBL5179538 | — | — | 1 | 5.62 |
| CHEMBL5196498 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545308 | ROCILETINIB | IC50 | = | 76.61 | nM | 7.12 |
| CHEMBL5206775 | — | IC50 | = | 364.2 | nM | 6.44 |
| CHEMBL5200495 | — | IC50 | = | 614.4 | nM | 6.21 |
| CHEMBL5201794 | — | IC50 | = | 647.9 | nM | 6.19 |
| CHEMBL5175891 | — | IC50 | = | 838.6 | nM | 6.08 |
| CHEMBL5204954 | — | IC50 | = | 1404.0 | nM | 5.85 |
| CHEMBL5179538 | — | IC50 | = | 2397.0 | nM | 5.62 |
| CHEMBL5196498 | — | IC50 | = | 3230.0 | nM | 5.49 |