Assay Detail
Binding
CHEMBL5115859
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Inhibition of N-terminus or C-terminus NLuc fused CDK11A (unknown origin) transfected in HEK293 cells by NanoBRET assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.07 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1989043 | — | — | 1 | 6.77 |
| CHEMBL5175800 | — | — | 1 | 6.72 |
| CHEMBL5180190 | — | — | 1 | 6.64 |
| CHEMBL5185990 | — | — | 1 | 6.64 |
| CHEMBL5185655 | — | — | 1 | 6.58 |
| CHEMBL5206282 | — | — | 1 | 6.48 |
| CHEMBL5200790 | — | — | 1 | 6.33 |
| CHEMBL5208491 | — | — | 1 | 6.24 |
| CHEMBL5173236 | — | — | 1 | 6.21 |
| CHEMBL5200963 | — | — | 1 | 6.16 |
| CHEMBL5184522 | — | — | 1 | 6.15 |
| CHEMBL5182610 | — | — | 1 | 6.10 |
| CHEMBL5171843 | — | — | 1 | 6.05 |
| CHEMBL5194816 | — | — | 1 | 6.00 |
| CHEMBL5203750 | — | — | 1 | 5.92 |
| CHEMBL5180130 | — | — | 1 | 5.92 |
| CHEMBL5180577 | — | — | 1 | 5.89 |
| CHEMBL5190264 | — | — | 1 | 5.82 |
| CHEMBL5180851 | — | — | 1 | 5.80 |
| CHEMBL5170651 | — | — | 1 | 5.80 |
| CHEMBL5199067 | — | — | 1 | 5.68 |
| CHEMBL5177982 | — | — | 1 | 5.66 |
| CHEMBL5169674 | — | — | 1 | 5.58 |
| CHEMBL5190514 | — | — | 1 | 5.47 |
| CHEMBL5178437 | — | — | 1 | 5.21 |
| CHEMBL5200515 | — | — | 1 | - |
| CHEMBL5207135 | — | — | 1 | - |
| CHEMBL5189171 | — | — | 1 | - |
| CHEMBL5195298 | — | — | 1 | - |
| CHEMBL5173735 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1989043 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5175800 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5180190 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5185990 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5185655 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5206282 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5200790 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5208491 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5173236 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL5200963 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5184522 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5182610 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5171843 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5194816 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5203750 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5180130 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5180577 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5190264 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5180851 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5170651 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5199067 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5177982 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5169674 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5190514 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5178437 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5200515 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5207135 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5189171 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5195298 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5173735 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5192162 | — | IC50 | > | 10000.0 | nM | - |