Assay Detail
Binding
CHEMBL5115862
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant full length His-tagged CDK9/Cyclin T1 expressed in Baculovirus expression system by Adapta assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.04 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5206282 | — | — | 1 | 8.10 |
| CHEMBL5200963 | — | — | 1 | 8.10 |
| CHEMBL5185655 | — | — | 1 | 7.96 |
| CHEMBL5180130 | — | — | 1 | 7.89 |
| CHEMBL5175800 | — | — | 1 | 7.66 |
| CHEMBL5171843 | — | — | 1 | 7.62 |
| CHEMBL5185990 | — | — | 1 | 7.57 |
| CHEMBL5184522 | — | — | 1 | 7.54 |
| CHEMBL5180851 | — | — | 1 | 7.52 |
| CHEMBL5169674 | — | — | 1 | 7.46 |
| CHEMBL1989043 | — | — | 1 | 7.36 |
| CHEMBL5200515 | — | — | 1 | 7.19 |
| CHEMBL5200790 | — | — | 1 | 7.16 |
| CHEMBL5178437 | — | — | 1 | 7.15 |
| CHEMBL5189171 | — | — | 1 | 7.11 |
| CHEMBL5203750 | — | — | 1 | 6.75 |
| CHEMBL5194816 | — | — | 1 | 6.75 |
| CHEMBL5173236 | — | — | 1 | 6.74 |
| CHEMBL5208491 | — | — | 1 | 6.73 |
| CHEMBL5180190 | — | — | 1 | 6.72 |
| CHEMBL5177982 | — | — | 1 | 6.68 |
| CHEMBL5190264 | — | — | 1 | 6.52 |
| CHEMBL5182610 | — | — | 1 | 6.50 |
| CHEMBL5199067 | — | — | 1 | 6.50 |
| CHEMBL5190514 | — | — | 1 | 6.33 |
| CHEMBL5170651 | — | — | 1 | 6.23 |
| CHEMBL5195298 | — | — | 1 | 5.85 |
| CHEMBL5180577 | — | — | 1 | 5.55 |
| CHEMBL5173735 | — | — | 1 | - |
| CHEMBL5207135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206282 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5200963 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5185655 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5180130 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5175800 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5171843 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5185990 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5184522 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5180851 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5169674 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1989043 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5200515 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5200790 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5178437 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5189171 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5203750 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5194816 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5173236 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL5208491 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL5180190 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL5177982 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5190264 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5182610 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL5199067 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL5190514 | — | IC50 | = | 463.0 | nM | 6.33 |
| CHEMBL5170651 | — | IC50 | = | 592.0 | nM | 6.23 |
| CHEMBL5195298 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL5180577 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL5173735 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5207135 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5192162 | — | IC50 | > | 10000.0 | nM | - |