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Assay Detail

CHEMBL5115940

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against ZIKV-SMGC-1 infected in human BHK cells incubated for 7 days by CellTiter 96 luminescent cell viability assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Zika virus
Cell Type BHK
Confidence 1 — Organism
Curated By Autocuration

Target

Zika virus (CHEMBL4296612)
Type ORGANISM
Organism Zika virus

Publication

Synthesis of 10,10'-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro.
Xiao Y, Yang J, Zou L, Wu P, Li W, Yan Y, Li Y, Li S, Song H, Zhong W, Qin Y.
Eur J Med Chem (2022) 238 : 114436 -114436
PubMed 35598412 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 6.06 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5201783 1 7.16
CHEMBL5205622 1 7.05
CHEMBL5185409 1 7.00
CHEMBL5182449 1 6.82
CHEMBL5190131 1 6.60
CHEMBL5170602 1 6.55
CHEMBL5195868 1 6.44
CHEMBL5188302 1 6.11
CHEMBL5199401 1 6.04
CHEMBL5201294 1 6.01
CHEMBL5197837 1 5.91
CHEMBL1630221 1 5.79
CHEMBL5177070 1 5.77
CHEMBL5192362 1 5.25
CHEMBL5178265 1 5.19
CHEMBL5188966 1 4.84
CHEMBL5183919 1 4.50
CHEMBL5202001 1 -
CHEMBL5186684 1 -
CHEMBL5175098 1 -
CHEMBL5203225 1 -
CHEMBL5177334 1 -
CHEMBL5191957 1 -
CHEMBL3393622 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5201783 IC50 = 70.0 nM 7.16
CHEMBL5205622 IC50 = 90.0 nM 7.05
CHEMBL5185409 IC50 = 100.0 nM 7.00
CHEMBL5182449 IC50 = 150.0 nM 6.82
CHEMBL5190131 IC50 = 250.0 nM 6.60
CHEMBL5170602 IC50 = 280.0 nM 6.55
CHEMBL5195868 IC50 = 360.0 nM 6.44
CHEMBL5188302 IC50 = 780.0 nM 6.11
CHEMBL5199401 IC50 = 910.0 nM 6.04
CHEMBL5201294 IC50 = 970.0 nM 6.01
CHEMBL5197837 IC50 = 1240.0 nM 5.91
CHEMBL1630221 IC50 = 1620.0 nM 5.79
CHEMBL5177070 IC50 = 1690.0 nM 5.77
CHEMBL5192362 IC50 = 5670.0 nM 5.25
CHEMBL5178265 IC50 = 6410.0 nM 5.19
CHEMBL5188966 IC50 = 14490.0 nM 4.84
CHEMBL5183919 IC50 = 31360.0 nM 4.50
CHEMBL5202001 IC50 - -
CHEMBL5186684 IC50 - -
CHEMBL5175098 IC50 - -
CHEMBL5203225 IC50 - -
CHEMBL5177334 IC50 - -
CHEMBL5191957 IC50 - -
CHEMBL3393622 IC50 > 300.0 nM -