Assay Detail
Binding
CHEMBL5116577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Kv7.2 (unknown origin) assessed as shifting of voltage dependent activation to more negative potentials by SyncroPatch assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily KQT member 2 (CHEMBL2476) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.84 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5185685 | — | — | 1 | 7.30 |
| CHEMBL5186399 | — | — | 1 | 6.01 |
| CHEMBL5200636 | — | — | 1 | 5.95 |
| CHEMBL5174263 | — | — | 1 | 5.65 |
| CHEMBL4458793 | — | — | 1 | 5.52 |
| CHEMBL41355 | EZOGABINE | 4.0 | 1 | 5.38 |
| CHEMBL5172000 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5185685 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5186399 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5200636 | — | EC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL5174263 | — | EC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL4458793 | — | EC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL41355 | EZOGABINE | EC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL5172000 | — | EC50 | = | 8590.0 | nM | 5.07 |