Assay Detail
Binding
CHEMBL5116582
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Kv7.2/3 (unknown origin) expressed in CHO cells co-expressing GFP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) (CHEMBL2221348) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.28 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4458793 | — | — | 1 | 7.75 |
| CHEMBL5185685 | — | — | 1 | 6.10 |
| CHEMBL5200636 | — | — | 1 | 5.79 |
| CHEMBL4549229 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4458793 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5185685 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5200636 | — | EC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL4549229 | — | EC50 | = | 3360.0 | nM | 5.47 |