Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O43526. Use UniProt O43526 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O43526 as the stable identity anchor, then attach disease evidence before program review.
Potassium voltage-gated channel subfamily KQT member 2
Review this target as Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3), mapped to UniProt O43526. ChEMBL maps the protein component as Potassium voltage-gated channel subfamily KQT member 2. Sequence length is 872 aa.
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This review treats Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) as ChEMBL target CHEMBL2221348, mapped to UniProt O43526. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | O43526 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Potassium voltage-gated channel subfamily KQT member 2 |
| UniProt Accession | O43526 |
| Component Type | Protein |
| Sequence Length | 872 aa |
Potassium voltage-gated channel subfamily KQT member 2
Review this target as Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3), mapped to UniProt O43526. ChEMBL maps the protein component as Potassium voltage-gated channel subfamily KQT member 2. Sequence length is 872 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5412763 | 8.01 | EC50 | 9.8 | Preclinical |
| CHEMBL2047506 | 8.0 | EC50 | 10.0 | Preclinical |
| CHEMBL4458793 | 7.75 | EC50 | 18.0 | Preclinical |
| CHEMBL4278049 | 7.7 | EC50 | 20.0 | Preclinical |
| CHEMBL598553 | 7.68 | EC50 | 21.0 | Preclinical |
| CHEMBL592297 | 7.64 | EC50 | 23.0 | Preclinical |
| CHEMBL3621438 | 7.62 | EC50 | 24.0 | Preclinical |
| CHEMBL599164 | 7.6 | EC50 | 25.0 | Preclinical |
| CHEMBL598126 | 7.57 | EC50 | 27.0 | Preclinical |
| CHEMBL599374 | 7.55 | EC50 | 28.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 33 | 96 | 6.5 |
| protein complex format | 14 | 2 | 7.4 |
| assay format | 4 | 15 | 6.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 44 | 6.3 |
| assay format | 1 | 1 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |