Compound Detail
CHEMBL5412763
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Basic Information
| ChEMBL ID | CHEMBL5412763 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FONLKDOANLSAGT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
435.4
MW (Da)
6.06
ALogP
3
HBA
1
HBD
32.3
PSA (Ų)
0.64
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) CHEMBL2221348 | EC50 | 8.01 | 8.01 | 9.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) | EC50 | = | 9.8 | nM | 8.01 | Agonist activity at Kv7.2/Kv7.3 (unknown origin) expressed in human HEK293 cells... | 37012671 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37012671 | 10.1021/acs.jmedchem.2c01975 | Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) | 1 |
Data from ChEMBL 36 via Core Engine