Assay Detail
Binding
CHEMBL5116812
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kbeta (unknown origin) incubated for 60 mins in the presence of ATP by Kinase-Glo luminescence assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 4H-benzo[e][1,3]oxazin-4-ones analogues of TGX-221 as inhibitors of PI3Kβ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.50 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5173094 | — | — | 1 | 7.31 |
| CHEMBL5204332 | — | — | 1 | 7.20 |
| CHEMBL1972466 | — | — | 1 | 7.19 |
| CHEMBL5176111 | — | — | 1 | 7.16 |
| CHEMBL5175866 | — | — | 1 | 7.14 |
| CHEMBL5175395 | — | — | 1 | 6.87 |
| CHEMBL5191049 | — | — | 1 | 6.82 |
| CHEMBL5202433 | — | — | 1 | 6.64 |
| CHEMBL5201399 | — | — | 1 | 6.62 |
| CHEMBL5203337 | — | — | 1 | 6.57 |
| CHEMBL5208867 | — | — | 1 | 6.55 |
| CHEMBL5207448 | — | — | 1 | 5.91 |
| CHEMBL5183615 | — | — | 1 | 5.84 |
| CHEMBL5193998 | — | — | 1 | 5.73 |
| CHEMBL5188598 | — | — | 1 | 5.61 |
| CHEMBL5174445 | — | — | 1 | 4.90 |
| CHEMBL5171155 | — | — | 1 | - |
| CHEMBL5172240 | — | — | 1 | - |
| CHEMBL5204523 | — | — | 1 | - |
| CHEMBL5175510 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5173094 | — | IC50 | = | 49.2 | nM | 7.31 |
| CHEMBL5204332 | — | IC50 | = | 62.7 | nM | 7.20 |
| CHEMBL1972466 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5176111 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5175866 | — | IC50 | = | 72.7 | nM | 7.14 |
| CHEMBL5175395 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL5191049 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL5202433 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL5201399 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5203337 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL5208867 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL5207448 | — | IC50 | = | 1219.0 | nM | 5.91 |
| CHEMBL5183615 | — | IC50 | = | 1428.0 | nM | 5.84 |
| CHEMBL5193998 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL5188598 | — | IC50 | = | 2435.0 | nM | 5.61 |
| CHEMBL5174445 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL5171155 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5172240 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5204523 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5175510 | — | IC50 | > | 20000.0 | nM | - |