Assay Detail
Functional
CHEMBL5116959
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Antiproliferative activity against human HCT-116 cells measured after 48 hrs by SRB assay
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of a new series of pyrazole derivatives: Discovery of potent and selective JNK3 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.44 | 5.80 |
| TGI | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 2 | 5.80 |
| CHEMBL5191468 | — | — | 2 | 5.79 |
| CHEMBL5179338 | — | — | 2 | 5.73 |
| CHEMBL5205920 | — | — | 2 | 5.71 |
| CHEMBL5182819 | — | — | 2 | 5.24 |
| CHEMBL7064 | — | — | 2 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL5191468 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL5179338 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL5205920 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL5182819 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL7064 | — | IC50 | = | 44570.0 | nM | 4.35 |
| CHEMBL1336 | SORAFENIB | TGI | = | 2510.0 | nM | - |
| CHEMBL7064 | — | TGI | > | 100000.0 | nM | - |
| CHEMBL5191468 | — | TGI | = | 5820.0 | nM | - |
| CHEMBL5205920 | — | TGI | = | 6330.0 | nM | - |
| CHEMBL5182819 | — | TGI | = | 17000.0 | nM | - |
| CHEMBL5179338 | — | TGI | > | 22000.0 | nM | - |