Assay Detail
Functional
CHEMBL5117004
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Antiproliferative activity against human WI-38 cells measured by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WI-38 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of a new series of pyrazole derivatives: Discovery of potent and selective JNK3 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.79 | 4.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205920 | — | — | 1 | 4.87 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 4.83 |
| CHEMBL5191468 | — | — | 1 | 4.77 |
| CHEMBL5183673 | — | — | 1 | 4.76 |
| CHEMBL5201911 | — | — | 1 | 4.73 |
| CHEMBL7064 | — | — | 1 | - |
| CHEMBL5182819 | — | — | 1 | - |
| CHEMBL5179338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205920 | — | IC50 | = | 13580.0 | nM | 4.87 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL5191468 | — | IC50 | = | 16840.0 | nM | 4.77 |
| CHEMBL5183673 | — | IC50 | = | 17420.0 | nM | 4.76 |
| CHEMBL5201911 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL7064 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5182819 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5179338 | — | IC50 | > | 20000.0 | nM | - |