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Assay Detail

CHEMBL5117015

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of JNK3 (unknown origin)
ChEMBL ↗
47
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 10 (CHEMBL2637) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis, and biological evaluation of a new series of pyrazole derivatives: Discovery of potent and selective JNK3 kinase inhibitors.
Abu Rabah RR, Sebastian A, Vunnam S, Sultan S, Tarazi H, Anbar HS, Shehata MK, Zaraei SO, Elgendy SM, Al Shamma SA, Omar HA, Al-Tel TH, El-Gamal MI.
Bioorg Med Chem (2022) 69 : 116894 -116894
PubMed 35764033 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 47 6.27 7.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL7064 — — 1 7.04
CHEMBL5191468 — — 2 7.01
CHEMBL5201911 — — 2 7.00
CHEMBL5196004 — — 2 6.72
CHEMBL5205920 — — 2 6.32
CHEMBL5183673 — — 2 6.28
CHEMBL5179126 — — 2 6.21
CHEMBL5190930 — — 2 6.00
CHEMBL5190777 — — 2 6.00
CHEMBL5177988 — — 2 6.00
CHEMBL5206891 — — 2 6.00
CHEMBL5182819 — — 2 6.00
CHEMBL5173811 — — 2 6.00
CHEMBL5190656 — — 2 6.00
CHEMBL5206209 — — 2 6.00
CHEMBL5180621 — — 2 6.00
CHEMBL5176396 — — 2 6.00
CHEMBL5175285 — — 2 6.00
CHEMBL5199545 — — 2 6.00
CHEMBL5171564 — — 2 6.00
CHEMBL5197538 — — 2 6.00
CHEMBL5174880 — — 2 6.00
CHEMBL5179338 — — 2 6.00
CHEMBL5178484 — — 2 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL7064 — IC50 = 90.5 nM 7.04
CHEMBL5191468 — IC50 = 97.72 nM 7.01
CHEMBL5191468 — IC50 = 97.4 nM 7.01
CHEMBL5201911 — IC50 = 100.0 nM 7.00
CHEMBL5201911 — IC50 = 99.0 nM 7.00
CHEMBL5196004 — IC50 = 189.5 nM 6.72
CHEMBL5196004 — IC50 = 190.55 nM 6.72
CHEMBL5205920 — IC50 = 473.9 nM 6.32
CHEMBL5205920 — IC50 = 478.63 nM 6.32
CHEMBL5183673 — IC50 = 524.81 nM 6.28
CHEMBL5183673 — IC50 = 526.4 nM 6.28
CHEMBL5179126 — IC50 = 613.8 nM 6.21
CHEMBL5179126 — IC50 = 616.6 nM 6.21
CHEMBL5176396 — IC50 = 1000.0 nM 6.00
CHEMBL5190777 — IC50 = 1000.0 nM 6.00
CHEMBL5190930 — IC50 = 1000.0 nM 6.00
CHEMBL5197538 — IC50 = 1000.0 nM 6.00
CHEMBL5171564 — IC50 = 1000.0 nM 6.00
CHEMBL5199545 — IC50 = 1000.0 nM 6.00
CHEMBL5175285 — IC50 = 1000.0 nM 6.00
CHEMBL5180621 — IC50 = 1000.0 nM 6.00
CHEMBL5190656 — IC50 = 1000.0 nM 6.00
CHEMBL5206209 — IC50 = 1000.0 nM 6.00
CHEMBL5178484 — IC50 = 1000.0 nM 6.00
CHEMBL5174880 — IC50 = 1000.0 nM 6.00
CHEMBL5179338 — IC50 = 1000.0 nM 6.00
CHEMBL5177988 — IC50 = 1000.0 nM 6.00
CHEMBL5206891 — IC50 = 1000.0 nM 6.00
CHEMBL5182819 — IC50 = 1000.0 nM 6.00
CHEMBL5173811 — IC50 = 1000.0 nM 6.00
CHEMBL5178484 — IC50 > 1000.0 nM -
CHEMBL5179338 — IC50 > 1000.0 nM -
CHEMBL5174880 — IC50 > 1000.0 nM -
CHEMBL5197538 — IC50 > 1000.0 nM -
CHEMBL5171564 — IC50 > 1000.0 nM -
CHEMBL5199545 — IC50 > 1000.0 nM -
CHEMBL5175285 — IC50 > 1000.0 nM -
CHEMBL5176396 — IC50 > 1000.0 nM -
CHEMBL5180621 — IC50 > 1000.0 nM -
CHEMBL5206209 — IC50 > 1000.0 nM -
CHEMBL5190656 — IC50 > 1000.0 nM -
CHEMBL5173811 — IC50 > 1000.0 nM -
CHEMBL5182819 — IC50 > 1000.0 nM -
CHEMBL5206891 — IC50 > 1000.0 nM -
CHEMBL5177988 — IC50 > 1000.0 nM -
CHEMBL5190777 — IC50 > 1000.0 nM -
CHEMBL5190930 — IC50 > 1000.0 nM -