Assay Detail
Binding
CHEMBL5117152
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Inhibition of COX-2 (unknown origin)
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of dual inhibitors of topoisomerase I and Cyclooxygenase-2 for colon cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.38 | 5.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121626 | TOLFENAMIC ACID | 2.0 | 1 | 5.93 |
| CHEMBL5206236 | — | — | 1 | 5.72 |
| CHEMBL5189018 | — | — | 1 | 5.64 |
| CHEMBL5171524 | — | — | 1 | 5.50 |
| CHEMBL5183520 | — | — | 1 | 5.45 |
| CHEMBL5199286 | — | — | 1 | 5.36 |
| CHEMBL5199367 | — | — | 1 | 5.20 |
| CHEMBL5188131 | — | — | 1 | 5.13 |
| CHEMBL5191274 | — | — | 1 | 5.08 |
| CHEMBL5209304 | — | — | 1 | 4.79 |
| CHEMBL5202793 | — | — | 1 | - |
| CHEMBL5208731 | — | — | 1 | - |
| CHEMBL5183580 | — | — | 1 | - |
| CHEMBL5180877 | — | — | 1 | - |
| CHEMBL5200862 | — | — | 1 | - |
| CHEMBL5206283 | — | — | 1 | - |
| CHEMBL5190248 | — | — | 1 | - |
| CHEMBL5176084 | — | — | 1 | - |
| CHEMBL5201631 | — | — | 1 | - |
| CHEMBL5171583 | — | — | 1 | - |
| CHEMBL5198879 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121626 | TOLFENAMIC ACID | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL5206236 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL5189018 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL5171524 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL5183520 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL5199286 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL5199367 | — | IC50 | = | 6380.0 | nM | 5.20 |
| CHEMBL5188131 | — | IC50 | = | 7370.0 | nM | 5.13 |
| CHEMBL5191274 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL5209304 | — | IC50 | = | 16240.0 | nM | 4.79 |
| CHEMBL5202793 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5208731 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5183580 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5180877 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5200862 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5206283 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5190248 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5176084 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5201631 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5171583 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5198879 | — | IC50 | > | 30000.0 | nM | - |