Assay Detail
Binding
CHEMBL5117299
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Inhibition of eGFP fused SARS-CoV2 main protease transfected in HEK293T/17 cells incubated for 72 hrs by fluorescence based flow cytometry analysis
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | HEK293T/17 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 6.55 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852855 | — | — | 1 | 7.52 |
| CHEMBL5190267 | — | — | 1 | 7.25 |
| CHEMBL5176166 | — | — | 1 | 7.01 |
| CHEMBL5178763 | — | — | 1 | 6.92 |
| CHEMBL5193629 | — | — | 1 | 6.85 |
| CHEMBL5203900 | — | — | 1 | 6.72 |
| CHEMBL5173899 | — | — | 1 | 6.64 |
| CHEMBL5177381 | — | — | 1 | 6.20 |
| CHEMBL5202077 | — | — | 1 | 6.18 |
| CHEMBL5203715 | — | — | 1 | 6.07 |
| CHEMBL5178556 | — | — | 1 | 5.82 |
| CHEMBL5201264 | — | — | 1 | 5.47 |
| CHEMBL5183770 | — | — | 1 | - |
| CHEMBL5202866 | — | — | 1 | - |
| CHEMBL5178875 | — | — | 1 | - |
| CHEMBL5205477 | — | — | 1 | - |
| CHEMBL5189578 | — | — | 1 | - |
| CHEMBL5172231 | — | — | 1 | - |
| CHEMBL5185670 | — | — | 1 | - |
| CHEMBL5169820 | — | — | 1 | - |
| CHEMBL5204033 | — | — | 1 | - |
| CHEMBL5171771 | — | — | 1 | - |
| CHEMBL5203726 | — | — | 1 | - |
| CHEMBL5208464 | — | — | 1 | - |
| CHEMBL5205992 | — | — | 1 | - |
| CHEMBL5199403 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852855 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5190267 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5176166 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL5178763 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5193629 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5203900 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5173899 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5177381 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5202077 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5203715 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5178556 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5201264 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5183770 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5202866 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5178875 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5205477 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5189578 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5172231 | — | EC50 | - | — | - | |
| CHEMBL5185670 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5169820 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5204033 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5171771 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5203726 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5208464 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5205992 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL5199403 | — | EC50 | > | 10000.0 | nM | - |