Assay Detail
Functional
CHEMBL5117327
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MD-231 cells measured by cell viability assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and bioactivity evaluation of macrocyclic benzo[b]pyrido[4,3-e][1,4]oxazine derivatives as novel Pim-1 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.66 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5199618 | — | — | 1 | 5.09 |
| CHEMBL5197665 | — | — | 1 | 4.91 |
| CHEMBL5189982 | — | — | 1 | 4.79 |
| CHEMBL5197400 | — | — | 1 | 4.72 |
| CHEMBL5205827 | — | — | 1 | 4.71 |
| CHEMBL5177750 | — | — | 1 | 4.59 |
| CHEMBL5204474 | — | — | 1 | 4.52 |
| CHEMBL5204548 | — | — | 1 | 4.46 |
| CHEMBL5187722 | — | — | 1 | 4.45 |
| CHEMBL5181648 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5199618 | — | IC50 | = | 8154.0 | nM | 5.09 |
| CHEMBL5197665 | — | IC50 | = | 12340.0 | nM | 4.91 |
| CHEMBL5189982 | — | IC50 | = | 16310.0 | nM | 4.79 |
| CHEMBL5197400 | — | IC50 | = | 19010.0 | nM | 4.72 |
| CHEMBL5205827 | — | IC50 | = | 19490.0 | nM | 4.71 |
| CHEMBL5177750 | — | IC50 | = | 25910.0 | nM | 4.59 |
| CHEMBL5204474 | — | IC50 | = | 29970.0 | nM | 4.52 |
| CHEMBL5204548 | — | IC50 | = | 34750.0 | nM | 4.46 |
| CHEMBL5187722 | — | IC50 | = | 35390.0 | nM | 4.45 |
| CHEMBL5181648 | — | IC50 | = | 44040.0 | nM | 4.36 |