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Compound Detail

CHEMBL5177750

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c1cc2c(cn1)Oc1ccc3cc1N2CCCCCNCCOCCO3

Basic Information

ChEMBL ID CHEMBL5177750
Phase Preclinical
Structure Type MOL
InChI Key NHFAGYDSLOTWQD-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

355.4
MW (Da)
3.49
ALogP
6
HBA
1
HBD
55.9
PSA (Ų)
0.78
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H25N3O3
MW 355.44
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -0.43

Activity Summary

IC50 2 meas. best 6.86

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Serine/threonine-protein kinase pim-1
CHEMBL2147
IC50 6.86 6.86 139.6 1
MDA-MB-231
CHEMBL400
IC50 4.59 4.59 25910.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
35779826 10.1016/j.bmcl.2022.128874 Serine/threonine-protein kinase pim-1 1
35779826 10.1016/j.bmcl.2022.128874 MDA-MB-231 1

Data from ChEMBL 36 via Core Engine