Assay Detail
Functional
CHEMBL5117635
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 L100I mutant infected in human MT4 cells assessed as reduction in viral replication by MTT assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 50 | 5.93 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.22 |
| CHEMBL2364608 | DORAVIRINE | 4.0 | 1 | 8.18 |
| CHEMBL5195851 | — | — | 1 | 7.80 |
| CHEMBL5207106 | — | — | 1 | 7.68 |
| CHEMBL5194948 | — | — | 1 | 7.62 |
| CHEMBL5185466 | — | — | 1 | 7.30 |
| CHEMBL5192492 | — | — | 1 | 7.16 |
| CHEMBL5188535 | — | — | 1 | 7.06 |
| CHEMBL5182552 | — | — | 1 | 7.05 |
| CHEMBL5192706 | — | — | 1 | 7.01 |
| CHEMBL5206584 | — | — | 1 | 6.16 |
| CHEMBL5193241 | — | — | 1 | 5.92 |
| CHEMBL5191658 | — | — | 1 | 5.87 |
| CHEMBL5194139 | — | — | 1 | 5.86 |
| CHEMBL5172232 | — | — | 1 | 5.82 |
| CHEMBL5208344 | — | — | 1 | 5.80 |
| CHEMBL5172391 | — | — | 1 | 5.80 |
| CHEMBL5181319 | — | — | 1 | 5.79 |
| CHEMBL5197565 | — | — | 1 | 5.79 |
| CHEMBL5203008 | — | — | 1 | 5.77 |
| CHEMBL5207715 | — | — | 1 | 5.76 |
| CHEMBL5179563 | — | — | 1 | 5.73 |
| CHEMBL5183448 | — | — | 1 | 5.73 |
| CHEMBL5188268 | — | — | 1 | 5.72 |
| CHEMBL5193795 | — | — | 1 | 5.67 |
| CHEMBL5184356 | — | — | 1 | 5.63 |
| CHEMBL5197675 | — | — | 1 | 5.63 |
| CHEMBL5170086 | — | — | 1 | 5.62 |
| CHEMBL5181444 | — | — | 1 | 5.56 |
| CHEMBL5209417 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2364608 | DORAVIRINE | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL5195851 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5207106 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5194948 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5185466 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5192492 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5188535 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL5182552 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL5192706 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL5206584 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5193241 | — | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL5191658 | — | EC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL5194139 | — | EC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL5172232 | — | EC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL5208344 | — | EC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL5172391 | — | EC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL5181319 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL5197565 | — | EC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL5203008 | — | EC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL5207715 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL5179563 | — | EC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL5183448 | — | EC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL5188268 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5193795 | — | EC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL5184356 | — | EC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL5197675 | — | EC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL5170086 | — | EC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL5181444 | — | EC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL5209417 | — | EC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL5192757 | — | EC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL5172383 | — | EC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL5171525 | — | EC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL5169999 | — | EC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL5208501 | — | EC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL5176462 | — | EC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL5175076 | — | EC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL5177801 | — | EC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL5196297 | — | EC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL5204226 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5206836 | — | EC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL5197858 | — | EC50 | = | 4830.0 | nM | 5.32 |
| CHEMBL5191334 | — | EC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL5205877 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5189516 | — | EC50 | = | 5610.0 | nM | 5.25 |
| CHEMBL5200651 | — | EC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL5172691 | — | EC50 | = | 7680.0 | nM | 5.12 |
| CHEMBL5199298 | — | EC50 | = | 7770.0 | nM | 5.11 |
| CHEMBL5181637 | — | EC50 | = | 9010.0 | nM | 5.04 |
| CHEMBL5176402 | — | EC50 | = | 10820.0 | nM | 4.97 |