Assay Detail
Functional
CHEMBL5117637
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 Y181C mutant infected in human MT4 cells assessed as reduction in viral replication by MTT assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 50 | 5.43 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.72 |
| CHEMBL2364608 | DORAVIRINE | 4.0 | 1 | 7.60 |
| CHEMBL5207106 | — | — | 1 | 7.27 |
| CHEMBL5194948 | — | — | 1 | 7.24 |
| CHEMBL5195851 | — | — | 1 | 6.92 |
| CHEMBL5185466 | — | — | 1 | 6.75 |
| CHEMBL5192706 | — | — | 1 | 6.68 |
| CHEMBL5188535 | — | — | 1 | 6.47 |
| CHEMBL5192492 | — | — | 1 | 6.35 |
| CHEMBL5182552 | — | — | 1 | 6.35 |
| CHEMBL5181319 | — | — | 1 | 5.33 |
| CHEMBL5206584 | — | — | 1 | 5.32 |
| CHEMBL5194139 | — | — | 1 | 5.32 |
| CHEMBL5203008 | — | — | 1 | 5.30 |
| CHEMBL5205877 | — | — | 1 | 5.26 |
| CHEMBL5181444 | — | — | 1 | 5.22 |
| CHEMBL5188268 | — | — | 1 | 5.22 |
| CHEMBL5191658 | — | — | 1 | 5.20 |
| CHEMBL5197565 | — | — | 1 | 5.20 |
| CHEMBL5172391 | — | — | 1 | 5.16 |
| CHEMBL5170086 | — | — | 1 | 5.15 |
| CHEMBL5172383 | — | — | 1 | 5.12 |
| CHEMBL5208344 | — | — | 1 | 5.08 |
| CHEMBL5179563 | — | — | 1 | 5.06 |
| CHEMBL5197675 | — | — | 1 | 5.05 |
| CHEMBL5183448 | — | — | 1 | 4.92 |
| CHEMBL5189516 | — | — | 1 | 4.87 |
| CHEMBL5199298 | — | — | 1 | 4.85 |
| CHEMBL5196297 | — | — | 1 | 4.83 |
| CHEMBL5193241 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2364608 | DORAVIRINE | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5207106 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5194948 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5195851 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5185466 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5192706 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5188535 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5192492 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5182552 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5181319 | — | EC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL5206584 | — | EC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL5194139 | — | EC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL5203008 | — | EC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL5205877 | — | EC50 | = | 5540.0 | nM | 5.26 |
| CHEMBL5181444 | — | EC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL5188268 | — | EC50 | = | 5960.0 | nM | 5.22 |
| CHEMBL5191658 | — | EC50 | = | 6380.0 | nM | 5.20 |
| CHEMBL5197565 | — | EC50 | = | 6260.0 | nM | 5.20 |
| CHEMBL5172391 | — | EC50 | = | 6910.0 | nM | 5.16 |
| CHEMBL5170086 | — | EC50 | = | 7140.0 | nM | 5.15 |
| CHEMBL5172383 | — | EC50 | = | 7510.0 | nM | 5.12 |
| CHEMBL5208344 | — | EC50 | = | 8360.0 | nM | 5.08 |
| CHEMBL5179563 | — | EC50 | = | 8640.0 | nM | 5.06 |
| CHEMBL5197675 | — | EC50 | = | 8830.0 | nM | 5.05 |
| CHEMBL5183448 | — | EC50 | = | 12140.0 | nM | 4.92 |
| CHEMBL5189516 | — | EC50 | = | 13430.0 | nM | 4.87 |
| CHEMBL5199298 | — | EC50 | = | 14150.0 | nM | 4.85 |
| CHEMBL5196297 | — | EC50 | = | 14720.0 | nM | 4.83 |
| CHEMBL5193241 | — | EC50 | = | 19440.0 | nM | 4.71 |
| CHEMBL5176462 | — | EC50 | = | 21330.0 | nM | 4.67 |
| CHEMBL5207715 | — | EC50 | = | 22270.0 | nM | 4.65 |
| CHEMBL5172232 | — | EC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL5208501 | — | EC50 | = | 38810.0 | nM | 4.41 |
| CHEMBL5172691 | — | EC50 | = | 38750.0 | nM | 4.41 |
| CHEMBL5176402 | — | EC50 | = | 39050.0 | nM | 4.41 |
| CHEMBL5200651 | — | EC50 | = | 39590.0 | nM | 4.40 |
| CHEMBL5181637 | — | EC50 | = | 42250.0 | nM | 4.37 |
| CHEMBL5204226 | — | EC50 | = | 48320.0 | nM | 4.32 |
| CHEMBL5209417 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5177801 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5169999 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5193795 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5206836 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5171525 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5175076 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5184356 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5191334 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5197858 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5192757 | — | EC50 | > | 35000.0 | nM | - |