Assay Detail
Functional
CHEMBL5117638
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 Y188L mutant infected in human MT4 cells assessed as reduction in viral replication by MTT assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 50 | 5.52 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.75 |
| CHEMBL5195851 | — | — | 1 | 6.44 |
| CHEMBL2364608 | DORAVIRINE | 4.0 | 1 | 6.30 |
| CHEMBL5192492 | — | — | 1 | 6.21 |
| CHEMBL5194948 | — | — | 1 | 6.12 |
| CHEMBL5207106 | — | — | 1 | 6.08 |
| CHEMBL5185466 | — | — | 1 | 6.06 |
| CHEMBL5182552 | — | — | 1 | 5.82 |
| CHEMBL5192706 | — | — | 1 | 5.78 |
| CHEMBL5188535 | — | — | 1 | 5.45 |
| CHEMBL5191658 | — | — | 1 | 4.41 |
| CHEMBL5183448 | — | — | 1 | 4.40 |
| CHEMBL5207715 | — | — | 1 | 4.38 |
| CHEMBL5208501 | — | — | 1 | 4.38 |
| CHEMBL5200651 | — | — | 1 | 4.35 |
| CHEMBL5206584 | — | — | 1 | 4.33 |
| CHEMBL5193795 | — | — | 1 | - |
| CHEMBL5205877 | — | — | 1 | - |
| CHEMBL5208344 | — | — | 1 | - |
| CHEMBL5181319 | — | — | 1 | - |
| CHEMBL5172383 | — | — | 1 | - |
| CHEMBL5172391 | — | — | 1 | - |
| CHEMBL5175076 | — | — | 1 | - |
| CHEMBL5197675 | — | — | 1 | - |
| CHEMBL5181444 | — | — | 1 | - |
| CHEMBL5188268 | — | — | 1 | - |
| CHEMBL5197565 | — | — | 1 | - |
| CHEMBL5192757 | — | — | 1 | - |
| CHEMBL5206836 | — | — | 1 | - |
| CHEMBL5181637 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5195851 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2364608 | DORAVIRINE | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5192492 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5194948 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5207106 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL5185466 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL5182552 | — | EC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL5192706 | — | EC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL5188535 | — | EC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL5191658 | — | EC50 | = | 38810.0 | nM | 4.41 |
| CHEMBL5183448 | — | EC50 | = | 39780.0 | nM | 4.40 |
| CHEMBL5208501 | — | EC50 | = | 41530.0 | nM | 4.38 |
| CHEMBL5207715 | — | EC50 | = | 41430.0 | nM | 4.38 |
| CHEMBL5200651 | — | EC50 | = | 44830.0 | nM | 4.35 |
| CHEMBL5206584 | — | EC50 | = | 46330.0 | nM | 4.33 |
| CHEMBL5193241 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5191334 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5204226 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5184356 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5171525 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5170086 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5203008 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5194139 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5169999 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5189516 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5196297 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5199298 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5176462 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5179563 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5177801 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5176402 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5209417 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5181444 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5193795 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5205877 | — | EC50 | = | 104240.0 | nM | - |
| CHEMBL5208344 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5181319 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5172383 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5172391 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5175076 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5197675 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5197858 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5188268 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5197565 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5192757 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5206836 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5181637 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5172691 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5172232 | — | EC50 | > | 35000.0 | nM | - |