Assay Detail
Functional
CHEMBL5117639
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 E138K mutant infected in human MT4 cells assessed as reduction in viral replication by MTT assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 50 | 5.82 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.22 |
| CHEMBL2364608 | DORAVIRINE | 4.0 | 1 | 8.12 |
| CHEMBL5207106 | — | — | 1 | 7.68 |
| CHEMBL5194948 | — | — | 1 | 7.60 |
| CHEMBL5195851 | — | — | 1 | 7.58 |
| CHEMBL5185466 | — | — | 1 | 7.21 |
| CHEMBL5182552 | — | — | 1 | 7.11 |
| CHEMBL5192492 | — | — | 1 | 7.09 |
| CHEMBL5188535 | — | — | 1 | 6.92 |
| CHEMBL5192706 | — | — | 1 | 6.82 |
| CHEMBL5206584 | — | — | 1 | 6.10 |
| CHEMBL5191658 | — | — | 1 | 6.00 |
| CHEMBL5183448 | — | — | 1 | 5.87 |
| CHEMBL5172391 | — | — | 1 | 5.86 |
| CHEMBL5203008 | — | — | 1 | 5.84 |
| CHEMBL5207715 | — | — | 1 | 5.82 |
| CHEMBL5208344 | — | — | 1 | 5.80 |
| CHEMBL5194139 | — | — | 1 | 5.74 |
| CHEMBL5188268 | — | — | 1 | 5.72 |
| CHEMBL5193241 | — | — | 1 | 5.71 |
| CHEMBL5181319 | — | — | 1 | 5.68 |
| CHEMBL5172232 | — | — | 1 | 5.67 |
| CHEMBL5181444 | — | — | 1 | 5.64 |
| CHEMBL5197565 | — | — | 1 | 5.62 |
| CHEMBL5175076 | — | — | 1 | 5.59 |
| CHEMBL5179563 | — | — | 1 | 5.51 |
| CHEMBL5170086 | — | — | 1 | 5.48 |
| CHEMBL5184356 | — | — | 1 | 5.45 |
| CHEMBL5197675 | — | — | 1 | 5.43 |
| CHEMBL5192757 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2364608 | DORAVIRINE | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL5207106 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5194948 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5195851 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5185466 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5182552 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL5192492 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5188535 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5192706 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5206584 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5191658 | — | EC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL5183448 | — | EC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL5172391 | — | EC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL5203008 | — | EC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL5207715 | — | EC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL5208344 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5194139 | — | EC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL5188268 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5193241 | — | EC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL5181319 | — | EC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL5172232 | — | EC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL5181444 | — | EC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL5197565 | — | EC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL5175076 | — | EC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL5179563 | — | EC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL5170086 | — | EC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL5184356 | — | EC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL5197675 | — | EC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL5192757 | — | EC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL5208501 | — | EC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL5193795 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5169999 | — | EC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL5205877 | — | EC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL5209417 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5191334 | — | EC50 | = | 5410.0 | nM | 5.27 |
| CHEMBL5206836 | — | EC50 | = | 6180.0 | nM | 5.21 |
| CHEMBL5171525 | — | EC50 | = | 6780.0 | nM | 5.17 |
| CHEMBL5177801 | — | EC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL5204226 | — | EC50 | = | 7060.0 | nM | 5.15 |
| CHEMBL5200651 | — | EC50 | = | 7720.0 | nM | 5.11 |
| CHEMBL5176402 | — | EC50 | = | 12240.0 | nM | 4.91 |
| CHEMBL5181637 | — | EC50 | = | 13870.0 | nM | 4.86 |
| CHEMBL5189516 | — | EC50 | = | 18470.0 | nM | 4.73 |
| CHEMBL5176462 | — | EC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL5199298 | — | EC50 | = | 20480.0 | nM | 4.69 |
| CHEMBL5196297 | — | EC50 | = | 21820.0 | nM | 4.66 |
| CHEMBL5172691 | — | EC50 | = | 23730.0 | nM | 4.62 |
| CHEMBL5172383 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL5197858 | — | EC50 | = | - | nM | - |