Assay Detail
Functional
CHEMBL5117932
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells harboring del18/T790M/C797S triple mutant assessed as cell growth inhibition incubated for 72 hrs by cell titre glo luminescence assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel anilinopyrimidine derivatives as potential EGFR<sup>T790M/C797S</sup> Inhibitors: Design, Synthesis, biological activity study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.64 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5203385 | — | — | 1 | 8.15 |
| CHEMBL5188940 | — | — | 1 | 8.10 |
| CHEMBL5180894 | — | — | 1 | 8.05 |
| CHEMBL5197545 | — | — | 1 | 7.92 |
| CHEMBL5206164 | — | — | 1 | 7.89 |
| CHEMBL5186680 | — | — | 1 | 7.89 |
| CHEMBL5188373 | — | — | 1 | 7.85 |
| CHEMBL5203220 | — | — | 1 | 7.85 |
| CHEMBL5180388 | — | — | 1 | 7.80 |
| CHEMBL5192223 | — | — | 1 | 7.70 |
| CHEMBL5193123 | — | — | 1 | 7.62 |
| CHEMBL5193149 | — | — | 1 | 7.55 |
| CHEMBL5179357 | — | — | 1 | 7.54 |
| CHEMBL5204749 | — | — | 1 | 7.52 |
| CHEMBL5195904 | — | — | 1 | 7.50 |
| CHEMBL5209094 | — | — | 1 | 7.47 |
| CHEMBL5178971 | — | — | 1 | 7.46 |
| CHEMBL5199678 | — | — | 1 | 7.43 |
| CHEMBL5195137 | — | — | 1 | 7.40 |
| CHEMBL5203041 | — | — | 1 | 7.36 |
| CHEMBL3545311 | BRIGATINIB | 4.0 | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5203385 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5188940 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5180894 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5197545 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5206164 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5186680 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5188373 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5203220 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5180388 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5192223 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5193123 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5193149 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5179357 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5204749 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5195904 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5209094 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5178971 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5199678 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5195137 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5203041 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3545311 | BRIGATINIB | IC50 | = | 433.0 | nM | 6.36 |