Assay Detail
Functional
CHEMBL5117933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by cell titre glo luminescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel anilinopyrimidine derivatives as potential EGFR<sup>T790M/C797S</sup> Inhibitors: Design, Synthesis, biological activity study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.14 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5179357 | — | — | 1 | 6.38 |
| CHEMBL5180894 | — | — | 1 | 6.31 |
| CHEMBL3545311 | BRIGATINIB | 4.0 | 1 | 6.15 |
| CHEMBL5199678 | — | — | 1 | 6.15 |
| CHEMBL5209094 | — | — | 1 | 6.14 |
| CHEMBL5203041 | — | — | 1 | 5.99 |
| CHEMBL5195137 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5179357 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL5180894 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3545311 | BRIGATINIB | IC50 | = | 709.0 | nM | 6.15 |
| CHEMBL5199678 | — | IC50 | = | 702.0 | nM | 6.15 |
| CHEMBL5209094 | — | IC50 | = | 731.0 | nM | 6.14 |
| CHEMBL5203041 | — | IC50 | = | 1014.0 | nM | 5.99 |
| CHEMBL5195137 | — | IC50 | = | 1297.0 | nM | 5.89 |