Assay Detail
Binding
CHEMBL5118480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human Sirt5 incubated for 1 hr by FLUOR DE LYS fluorometric microplate reader assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial (CHEMBL2163183) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.99 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201346 | BALSALAZIDE | 4.0 | 1 | 5.28 |
| CHEMBL5204662 | — | — | 1 | 5.14 |
| CHEMBL5176252 | — | — | 1 | 5.07 |
| CHEMBL5171069 | — | — | 1 | 4.94 |
| CHEMBL5188284 | — | — | 1 | 4.90 |
| CHEMBL5205195 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201346 | BALSALAZIDE | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5204662 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5176252 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5171069 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL5188284 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL5205195 | — | IC50 | = | 23600.0 | nM | 4.63 |