Assay Detail
Binding
CHEMBL5118656
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SMYD2 overexpressing human KYSE-150 cells assessed as SMYD2 assessed as reduction in BTF3 monomethylation by Western blot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | KYSE-150 cell line |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Protein Lysine Methyltransferase SMYD2: A Promising Small Molecule Target for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.03 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5187983 | — | — | 1 | 8.54 |
| CHEMBL5197760 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5187983 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5197760 | — | IC50 | = | 31.0 | nM | 7.51 |