Assay Detail
Binding
CHEMBL5118940
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Inhibition of human MMP-1 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins followed by susbstrate addition by photon-counter spectrophotometer analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Inhibitors of Medium-Size S1' Pocket Matrix Metalloproteinases: A Stepping Stone of Future Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.46 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3670693 | — | — | 1 | 4.75 |
| CHEMBL5191016 | — | — | 1 | 4.17 |
| CHEMBL5190158 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3670693 | — | Ki | = | 17900.0 | nM | 4.75 |
| CHEMBL5191016 | — | Ki | = | 67000.0 | nM | 4.17 |
| CHEMBL5190158 | — | Ki | > | 100000.0 | nM | - |