Assay Detail
Binding
CHEMBL5118944
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Inhibition of MMP-1 (unknown origin)
31
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Inhibitors of Medium-Size S1' Pocket Matrix Metalloproteinases: A Stepping Stone of Future Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.59 | 8.82 |
| Ki | 13 | 6.54 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | 2.0 | 2 | 9.40 |
| CHEMBL5205063 | — | — | 1 | 8.52 |
| CHEMBL5175770 | — | — | 1 | 8.52 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.30 |
| CHEMBL5187653 | — | — | 2 | 8.10 |
| CHEMBL473539 | — | — | 1 | 8.08 |
| CHEMBL2107228 | SOLIMASTAT | 2.0 | 1 | 8.00 |
| CHEMBL5175662 | — | — | 1 | 7.60 |
| CHEMBL85030 | — | — | 2 | 7.48 |
| CHEMBL34085 | — | — | 1 | 6.30 |
| CHEMBL1801046 | — | — | 1 | 6.23 |
| CHEMBL5172839 | — | — | 1 | 5.75 |
| CHEMBL50228 | — | — | 1 | 5.60 |
| CHEMBL40143 | — | — | 1 | 5.34 |
| CHEMBL100570 | — | — | 1 | 5.30 |
| CHEMBL5184549 | — | — | 1 | 4.35 |
| CHEMBL483857 | — | — | 1 | 4.14 |
| CHEMBL5182668 | — | — | 1 | - |
| CHEMBL5177819 | — | — | 1 | - |
| CHEMBL5199189 | — | — | 1 | - |
| CHEMBL178590 | — | — | 1 | - |
| CHEMBL74539 | — | — | 1 | - |
| CHEMBL5198463 | — | — | 1 | - |
| CHEMBL41943 | — | — | 1 | - |
| CHEMBL485492 | — | — | 1 | - |
| CHEMBL445971 | — | — | 1 | - |
| CHEMBL5176328 | — | — | 1 | - |
| CHEMBL1200699 | DOXYCYCLINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL19611 | ILOMASTAT | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5205063 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5175770 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5187653 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL473539 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL5187653 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2107228 | SOLIMASTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5175662 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL85030 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL85030 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL34085 | — | Ki | = | 496.0 | nM | 6.30 |
| CHEMBL1801046 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL5172839 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL50228 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL40143 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL100570 | — | Ki | = | 4949.0 | nM | 5.30 |
| CHEMBL5184549 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL483857 | — | Ki | = | 73000.0 | nM | 4.14 |
| CHEMBL5177819 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL178590 | — | IC50 | = | 380000.0 | nM | - |
| CHEMBL1200699 | DOXYCYCLINE | IC50 | > | 400000.0 | nM | - |
| CHEMBL41943 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL485492 | — | Ki | > | 154000.0 | nM | - |
| CHEMBL445971 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL5182668 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5199189 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5198463 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5176328 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL74539 | — | Ki | > | 5000.0 | nM | - |