Assay Detail
Binding
CHEMBL5118949
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Inhibition of MMP-9 (unknown origin)
30
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Inhibitors of Medium-Size S1' Pocket Matrix Metalloproteinases: A Stepping Stone of Future Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.12 | 9.59 |
| Ki | 13 | 7.26 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | 2.0 | 2 | 9.70 |
| CHEMBL473539 | — | — | 1 | 9.59 |
| CHEMBL1801046 | — | — | 1 | 9.24 |
| CHEMBL5174280 | — | — | 1 | 9.15 |
| CHEMBL5205063 | — | — | 1 | 9.00 |
| CHEMBL5205275 | — | — | 1 | 8.92 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.52 |
| CHEMBL5187653 | — | — | 2 | 8.52 |
| CHEMBL5206844 | — | — | 1 | 8.45 |
| CHEMBL85030 | — | — | 2 | 8.10 |
| CHEMBL5177819 | — | — | 1 | 7.80 |
| CHEMBL34085 | — | — | 1 | 7.68 |
| CHEMBL5175662 | — | — | 1 | 7.60 |
| CHEMBL100570 | — | — | 1 | 7.33 |
| CHEMBL5175770 | — | — | 1 | 7.23 |
| CHEMBL2107228 | SOLIMASTAT | 2.0 | 1 | 7.16 |
| CHEMBL40143 | — | — | 1 | 6.92 |
| CHEMBL5172839 | — | — | 1 | 6.85 |
| CHEMBL445971 | — | — | 1 | 6.75 |
| CHEMBL74539 | — | — | 1 | 6.52 |
| CHEMBL483857 | — | — | 1 | 6.40 |
| CHEMBL41943 | — | — | 1 | 5.92 |
| CHEMBL50228 | — | — | 1 | 5.18 |
| CHEMBL485492 | — | — | 1 | 4.47 |
| CHEMBL178590 | — | — | 1 | - |
| CHEMBL5184549 | — | — | 1 | - |
| CHEMBL1434 | MINOCYCLINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL473539 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL19611 | ILOMASTAT | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1801046 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL5174280 | — | IC50 | = | 0.704 | nM | 9.15 |
| CHEMBL5205063 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5205275 | — | IC50 | = | 1.19 | nM | 8.92 |
| CHEMBL5187653 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5187653 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5206844 | — | IC50 | = | 3.571 | nM | 8.45 |
| CHEMBL85030 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL85030 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5177819 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL34085 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL5175662 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL100570 | — | Ki | = | 46.7 | nM | 7.33 |
| CHEMBL5175770 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL2107228 | SOLIMASTAT | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL40143 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5172839 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL445971 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL74539 | — | Ki | = | 301.0 | nM | 6.52 |
| CHEMBL483857 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL41943 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL50228 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL485492 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL1434 | MINOCYCLINE | IC50 | = | 180000.0 | nM | - |
| CHEMBL5184549 | — | Ki | > | 26000.0 | nM | - |
| CHEMBL178590 | — | IC50 | = | 212000.0 | nM | - |