Assay Detail
Functional
CHEMBL5120702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BAF3 cells harboring EGFR L858R/T790M mutant after 72 hrs by resazurin dye-based fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.89 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4558324 | LAZERTINIB | 4.0 | 1 | 8.13 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.85 |
| CHEMBL4098072 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4558324 | LAZERTINIB | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3353410 | OSIMERTINIB | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4098072 | — | EC50 | = | 21.0 | nM | 7.68 |