Assay Detail
Functional
CHEMBL5120717
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BAF3 cells harboring EGFR L858R mutant after 72 hrs by resazurin dye-based fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.70 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4098072 | — | — | 1 | 9.29 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 8.49 |
| CHEMBL4558324 | LAZERTINIB | 4.0 | 1 | 8.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4098072 | — | EC50 | = | 0.51 | nM | 9.29 |
| CHEMBL3353410 | OSIMERTINIB | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4558324 | LAZERTINIB | EC50 | = | 4.8 | nM | 8.32 |