Assay Detail
Binding
CHEMBL5120719
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Protac activity at E3 ubiquitin ligase/JAK2 in human MHH-CALL-4 cells assessed as E3 ubiquitin ligase mediated JAK2 degradation incubated for 32 hrs by immunoblotting analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MHHCALL4 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Potent PROTACs for the Potential Treatment of Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 8.43 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4741262 | — | — | 1 | 9.70 |
| CHEMBL5195930 | — | — | 1 | 9.30 |
| CHEMBL4790924 | — | — | 1 | 9.30 |
| CHEMBL4742130 | — | — | 1 | 9.27 |
| CHEMBL4789389 | — | — | 1 | 9.05 |
| CHEMBL4759504 | — | — | 1 | 8.57 |
| CHEMBL4784942 | — | — | 1 | 8.41 |
| CHEMBL4764854 | — | — | 1 | 7.82 |
| CHEMBL4744617 | — | — | 1 | 6.91 |
| CHEMBL4781392 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4741262 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5195930 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4790924 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4742130 | — | EC50 | = | 0.54 | nM | 9.27 |
| CHEMBL4789389 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4759504 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4784942 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4764854 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4744617 | — | EC50 | = | 122.0 | nM | 6.91 |
| CHEMBL4781392 | — | EC50 | = | 1100.0 | nM | 5.96 |