Compound Detail
CHEMBL5195930
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CCCn1cc(-c2nc(Nc3ccc(C(=O)NCCCCCc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)nc3[nH]ccc23)cn1
Basic Information
| ChEMBL ID | CHEMBL5195930 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YJQZQVOPZCTYQO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
673.8
MW (Da)
4.88
ALogP
9
HBA
4
HBD
167.0
PSA (Ų)
0.10
QED
1
Ro5 Violations
13
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 9.3 | 9.3 | 0.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 0.5 | nM | 9.3 | Protac activity at E3 ubiquitin ligase/JAK2 in human MHH-CALL-4 cells assessed a... | 36518705 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36518705 | 10.1021/acsmedchemlett.2c00457 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine