Assay Detail
Functional
CHEMBL5121091
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 NL4-3 infected in human MT4 cells assessed as inhibition of viral replication by Nano-Glo luciferase assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from <i>Wikstroemia lamatsoensis</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.05 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3741746 | — | — | 1 | 10.15 |
| CHEMBL5078905 | — | — | 1 | 9.74 |
| CHEMBL4744104 | — | — | 1 | 8.42 |
| CHEMBL2375488 | — | — | 1 | 7.89 |
| CHEMBL5190830 | — | — | 1 | - |
| CHEMBL5181689 | — | — | 1 | - |
| CHEMBL4776932 | — | — | 1 | - |
| CHEMBL4741288 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3741746 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL5078905 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL4744104 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL2375488 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL5190830 | — | IC50 | > | 41.0 | nM | - |
| CHEMBL5181689 | — | IC50 | > | 41.0 | nM | - |
| CHEMBL4776932 | — | IC50 | > | 41.0 | nM | - |
| CHEMBL4741288 | — | IC50 | > | 41.0 | nM | - |