Assay Detail
Functional
CHEMBL5122967
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Antiproliferative activity against human C6 cells measured after 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 3-arylisoquinoline derivatives as topoisomerase I and II dual inhibitors for the therapy of liver cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.66 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.09 |
| CHEMBL5204165 | — | — | 1 | 5.00 |
| CHEMBL5191703 | — | — | 1 | 4.91 |
| CHEMBL5207176 | — | — | 1 | 4.89 |
| CHEMBL5191412 | — | — | 1 | 4.80 |
| CHEMBL5206984 | — | — | 1 | 4.75 |
| CHEMBL5189105 | — | — | 1 | 4.74 |
| CHEMBL5170486 | — | — | 1 | 4.72 |
| CHEMBL5193154 | — | — | 1 | 4.70 |
| CHEMBL5185656 | — | — | 1 | 4.68 |
| CHEMBL5198581 | — | — | 1 | 4.67 |
| CHEMBL5194242 | — | — | 1 | 4.64 |
| CHEMBL5208456 | — | — | 1 | 4.57 |
| CHEMBL5192088 | — | — | 1 | 4.57 |
| CHEMBL5205570 | — | — | 1 | 4.50 |
| CHEMBL5205384 | — | — | 1 | 4.50 |
| CHEMBL5184434 | — | — | 1 | 4.45 |
| CHEMBL5203514 | — | — | 1 | 4.35 |
| CHEMBL5193812 | — | — | 1 | 4.03 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL5204165 | — | IC50 | = | 9890.0 | nM | 5.00 |
| CHEMBL5191703 | — | IC50 | = | 12380.0 | nM | 4.91 |
| CHEMBL5207176 | — | IC50 | = | 12880.0 | nM | 4.89 |
| CHEMBL5191412 | — | IC50 | = | 15870.0 | nM | 4.80 |
| CHEMBL5206984 | — | IC50 | = | 17590.0 | nM | 4.75 |
| CHEMBL5189105 | — | IC50 | = | 18010.0 | nM | 4.74 |
| CHEMBL5170486 | — | IC50 | = | 19130.0 | nM | 4.72 |
| CHEMBL5193154 | — | IC50 | = | 19960.0 | nM | 4.70 |
| CHEMBL5185656 | — | IC50 | = | 20920.0 | nM | 4.68 |
| CHEMBL5198581 | — | IC50 | = | 21340.0 | nM | 4.67 |
| CHEMBL5194242 | — | IC50 | = | 22680.0 | nM | 4.64 |
| CHEMBL5208456 | — | IC50 | = | 27240.0 | nM | 4.57 |
| CHEMBL5192088 | — | IC50 | = | 27010.0 | nM | 4.57 |
| CHEMBL5205570 | — | IC50 | = | 31660.0 | nM | 4.50 |
| CHEMBL5205384 | — | IC50 | = | 31940.0 | nM | 4.50 |
| CHEMBL5184434 | — | IC50 | = | 35860.0 | nM | 4.45 |
| CHEMBL5203514 | — | IC50 | = | 44210.0 | nM | 4.35 |
| CHEMBL5193812 | — | IC50 | = | 92880.0 | nM | 4.03 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | < | 1850.0 | nM | - |
| CHEMBL44657 | ETOPOSIDE | IC50 | < | 1850.0 | nM | - |