Assay Detail
Functional
CHEMBL5122968
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Antiproliferative activity against human U87 cells measured after 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 3-arylisoquinoline derivatives as topoisomerase I and II dual inhibitors for the therapy of liver cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.39 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.29 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.07 |
| CHEMBL5207176 | — | — | 1 | 4.26 |
| CHEMBL5170486 | — | — | 1 | 4.24 |
| CHEMBL5191412 | — | — | 1 | 4.23 |
| CHEMBL5191703 | — | — | 1 | 4.22 |
| CHEMBL5198581 | — | — | 1 | 4.19 |
| CHEMBL5185656 | — | — | 1 | 4.04 |
| CHEMBL5208456 | — | — | 1 | 4.00 |
| CHEMBL5189105 | — | — | 1 | - |
| CHEMBL5203514 | — | — | 1 | - |
| CHEMBL5184434 | — | — | 1 | - |
| CHEMBL5193812 | — | — | 1 | - |
| CHEMBL5192088 | — | — | 1 | - |
| CHEMBL5206984 | — | — | 1 | - |
| CHEMBL5193154 | — | — | 1 | - |
| CHEMBL5205570 | — | — | 1 | - |
| CHEMBL5205384 | — | — | 1 | - |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL5194242 | — | — | 1 | - |
| CHEMBL5204165 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 8460.0 | nM | 5.07 |
| CHEMBL5207176 | — | IC50 | = | 54620.0 | nM | 4.26 |
| CHEMBL5170486 | — | IC50 | = | 57430.0 | nM | 4.24 |
| CHEMBL5191412 | — | IC50 | = | 58540.0 | nM | 4.23 |
| CHEMBL5191703 | — | IC50 | = | 60710.0 | nM | 4.22 |
| CHEMBL5198581 | — | IC50 | = | 64830.0 | nM | 4.19 |
| CHEMBL5185656 | — | IC50 | = | 91530.0 | nM | 4.04 |
| CHEMBL5208456 | — | IC50 | = | 99500.0 | nM | 4.00 |
| CHEMBL5189105 | — | IC50 | = | 104220.0 | nM | - |
| CHEMBL5203514 | — | IC50 | = | 138240.0 | nM | - |
| CHEMBL5184434 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL5193812 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL5192088 | — | IC50 | = | 123920.0 | nM | - |
| CHEMBL5206984 | — | IC50 | = | 134230.0 | nM | - |
| CHEMBL5193154 | — | IC50 | = | 117240.0 | nM | - |
| CHEMBL5205570 | — | IC50 | = | 108340.0 | nM | - |
| CHEMBL5205384 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL65 | CAMPTOTHECIN | IC50 | < | 1850.0 | nM | - |
| CHEMBL5194242 | — | IC50 | = | 120420.0 | nM | - |
| CHEMBL5204165 | — | IC50 | > | 150000.0 | nM | - |