Assay Detail
Binding
CHEMBL5123370
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK9/Cyclin T (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
From Structure Modification to Drug Launch: A Systematic Review of the Ongoing Development of Cyclin-Dependent Kinase Inhibitors for Multiple Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.24 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4756595 | ENITOCICLIB | 1.0 | 1 | 8.52 |
| CHEMBL4754493 | BTX-A51 | 1.0 | 1 | 8.40 |
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | 8.40 |
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 8.40 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | 8.00 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4756595 | ENITOCICLIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4754493 | BTX-A51 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL296468 | BMS-387032 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2103840 | DINACICLIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL445813 | AT-7519 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 20.0 | nM | 7.70 |