Assay Detail
Binding
CHEMBL5123379
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK7/Cyclin H (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 7/ cyclin H (CHEMBL2111288) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
From Structure Modification to Drug Launch: A Systematic Review of the Ongoing Development of Cyclin-Dependent Kinase Inhibitors for Multiple Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.02 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 9.34 |
| CHEMBL4754493 | BTX-A51 | 1.0 | 1 | 8.89 |
| CHEMBL4442620 | RONICICLIB | 2.0 | 1 | 7.60 |
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | 7.21 |
| CHEMBL4741442 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14762 | SELICICLIB | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL4754493 | BTX-A51 | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4442620 | RONICICLIB | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL296468 | BMS-387032 | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4741442 | — | IC50 | = | 85.0 | nM | 7.07 |