Assay Detail
Functional
CHEMBL5123641
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 7 days by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational design, synthesis and biological evaluation of dual PARP-1/2 and TNKS1/2 inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.83 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5189723 | — | — | 1 | 6.29 |
| CHEMBL5174780 | — | — | 1 | 6.16 |
| CHEMBL5176874 | — | — | 1 | 6.12 |
| CHEMBL5172909 | — | — | 1 | 5.98 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 5.25 |
| CHEMBL3644587 | 2X-121 | 2.0 | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5189723 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5174780 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5176874 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5172909 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 5560.0 | nM | 5.25 |
| CHEMBL3644587 | 2X-121 | IC50 | = | 6710.0 | nM | 5.17 |