Assay Detail
Binding
CHEMBL5124392
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Inhibition of BTK (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Medicinal Chemistry Strategies for the Development of Bruton's Tyrosine Kinase Inhibitors against Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.90 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4111143 | — | — | 1 | 9.70 |
| CHEMBL4109377 | — | — | 1 | 9.70 |
| CHEMBL5200336 | — | — | 1 | 9.52 |
| CHEMBL5175002 | — | — | 1 | 8.96 |
| CHEMBL4107779 | — | — | 1 | 8.85 |
| CHEMBL5204333 | — | — | 1 | 7.97 |
| CHEMBL3942924 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4111143 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4109377 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5200336 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5175002 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4107779 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5204333 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL3942924 | — | IC50 | = | 26.0 | nM | 7.58 |