Assay Detail
Functional
CHEMBL5125087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-ferroptotic activity against RSL3-induced ferroptosis in human HT-22 cells assessed as cell viability measured after 24 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HT-22 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ferroptosis Inhibitory Aromatic Abietane Diterpenoids from <i>Ajuga decumbens</i> and Structural Revision of Two 3,4-Epoxy Group-Containing Abietanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.73 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205600 | — | — | 1 | 7.25 |
| CHEMBL5192196 | — | — | 1 | 7.12 |
| CHEMBL3633556 | — | — | 1 | 7.09 |
| CHEMBL5187862 | — | — | 1 | 6.51 |
| CHEMBL5208748 | — | — | 1 | 6.46 |
| CHEMBL5193018 | — | — | 1 | 6.39 |
| CHEMBL4166690 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205600 | — | EC50 | = | 56.1 | nM | 7.25 |
| CHEMBL5192196 | — | EC50 | = | 76.2 | nM | 7.12 |
| CHEMBL3633556 | — | EC50 | = | 81.2 | nM | 7.09 |
| CHEMBL5187862 | — | EC50 | = | 308.5 | nM | 6.51 |
| CHEMBL5208748 | — | EC50 | = | 347.5 | nM | 6.46 |
| CHEMBL5193018 | — | EC50 | = | 406.2 | nM | 6.39 |
| CHEMBL4166690 | — | EC50 | = | 526.5 | nM | 6.28 |