Assay Detail
Functional
CHEMBL5125641
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Antitrypanosomal activity against Trypanosoma brucei brucei incubated for 24 hrs by ATPlite assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.68 | 5.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5190766 | — | — | 1 | 5.95 |
| CHEMBL5205818 | — | — | 1 | 5.89 |
| CHEMBL5209133 | — | — | 1 | 5.86 |
| CHEMBL5186393 | — | — | 1 | 5.82 |
| CHEMBL5207517 | — | — | 1 | 5.82 |
| CHEMBL5200091 | — | — | 1 | 5.81 |
| CHEMBL5170687 | — | — | 1 | 5.78 |
| CHEMBL5175052 | — | — | 1 | 5.68 |
| CHEMBL5198708 | — | — | 1 | 5.64 |
| CHEMBL5176432 | — | — | 1 | 5.50 |
| CHEMBL5173102 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5190766 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL5205818 | — | EC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL5209133 | — | EC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL5186393 | — | EC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL5207517 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5200091 | — | EC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL5170687 | — | EC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL5175052 | — | EC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL5198708 | — | EC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL5176432 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5173102 | — | EC50 | = | 19790.0 | nM | 4.70 |