Assay Detail
Binding
CHEMBL5126035
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Inhibition of human SHP1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 6 (CHEMBL3166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrrospirones K-Q, Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus <i>Penicillium</i> sp. SCSIO 41512.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.47 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3322530 | — | — | 1 | 6.54 |
| CHEMBL5192236 | — | — | 1 | 4.20 |
| CHEMBL5175490 | — | — | 1 | 4.10 |
| CHEMBL5204780 | — | — | 1 | 4.00 |
| CHEMBL5209090 | — | — | 1 | 4.00 |
| CHEMBL5181027 | — | — | 1 | 4.00 |
| CHEMBL5189251 | — | — | 1 | - |
| CHEMBL5171831 | — | — | 1 | - |
| CHEMBL5192788 | — | — | 1 | - |
| CHEMBL5192054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3322530 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5192236 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL5175490 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL5204780 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5209090 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5181027 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5189251 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL5171831 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL5192788 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL5192054 | — | IC50 | = | 200000.0 | nM | - |