Assay Detail
Functional
CHEMBL5126793
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Cytotoxicity against human HL-60 cells assessed as cell growth inhibition
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.41 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 7.22 |
| CHEMBL5187702 | — | — | 1 | 5.60 |
| CHEMBL5175907 | — | — | 1 | - |
| CHEMBL5176801 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5187702 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5175907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5176801 | — | IC50 | > | 100000.0 | nM | - |