Assay Detail
Functional
CHEMBL5126844
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Antagonist activity at human adenosine A2A receptor
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Adenosine receptor antagonists: Recent advances and therapeutic perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.26 | 7.22 |
| Ki | 1 | 8.11 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3951351 | — | — | 1 | 8.11 |
| CHEMBL5182020 | — | — | 1 | 7.22 |
| CHEMBL5172541 | — | — | 1 | 6.26 |
| CHEMBL1939337 | — | — | 1 | 6.26 |
| CHEMBL5173144 | — | — | 1 | 6.26 |
| CHEMBL5206639 | — | — | 1 | 6.26 |
| CHEMBL5207175 | — | — | 1 | 5.78 |
| CHEMBL5193510 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3951351 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL5182020 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5172541 | — | IC50 | = | 545.7 | nM | 6.26 |
| CHEMBL1939337 | — | IC50 | = | 545.7 | nM | 6.26 |
| CHEMBL5173144 | — | IC50 | = | 545.7 | nM | 6.26 |
| CHEMBL5206639 | — | IC50 | = | 545.7 | nM | 6.26 |
| CHEMBL5207175 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL5193510 | — | IC50 | = | 1800.0 | nM | 5.75 |