Assay Detail
Binding
CHEMBL5127028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DYRK1B (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (CHEMBL5543) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.02 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386747 | — | — | 1 | 9.55 |
| CHEMBL3894571 | — | — | 1 | 9.23 |
| CHEMBL2386748 | — | — | 1 | 8.97 |
| CHEMBL3971170 | — | — | 1 | 8.79 |
| CHEMBL2386764 | — | — | 1 | 8.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386747 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL3894571 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL2386748 | — | IC50 | = | 1.07 | nM | 8.97 |
| CHEMBL3971170 | — | IC50 | = | 1.63 | nM | 8.79 |
| CHEMBL2386764 | — | IC50 | = | 2.83 | nM | 8.55 |