Assay Detail
Binding
CHEMBL5127039
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AChE
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.42 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5208529 | — | — | 1 | 6.85 |
| CHEMBL5181664 | — | — | 1 | 6.67 |
| CHEMBL5208725 | — | — | 1 | 6.65 |
| CHEMBL5186753 | — | — | 1 | 6.27 |
| CHEMBL5201779 | — | — | 1 | 6.09 |
| CHEMBL3323035 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5208529 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL5181664 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL5208725 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL5186753 | — | IC50 | = | 535.0 | nM | 6.27 |
| CHEMBL5201779 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL3323035 | — | IC50 | = | 1100.0 | nM | 5.96 |