Assay Detail
Binding
CHEMBL5127262
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BLK (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Review of the development of BTK inhibitors in overcoming the clinical limitations of ibrutinib.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.18 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 10.00 |
| CHEMBL5193128 | — | — | 1 | 8.60 |
| CHEMBL4071161 | TIRABRUTINIB | 4.0 | 1 | 5.95 |
| CHEMBL5187554 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5193128 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4071161 | TIRABRUTINIB | IC50 | = | 1133.0 | nM | 5.95 |
| CHEMBL5187554 | — | IC50 | > | 1000.0 | nM | - |